Munir Pirmohamed Selected Research

Carbamazepine (Tegretol)

1/2021	Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.
11/2019	Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.
1/2019	Controversies in drug allergy: Testing for delayed reactions.
1/2018	Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.
1/2018	Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
1/2017	The HLA-A*31:01 allele: influence on carbamazepine treatment.
1/2017	Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients.
12/2016	Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.
11/2015	Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery.
8/2015	New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity.

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Munir Pirmohamed Research Topics

Disease

62	Hypersensitivity (Allergy) 01/2022 - 09/2002
35	Drug-Related Side Effects and Adverse Reactions 01/2022 - 10/2003
20	Epilepsy (Aura) 01/2022 - 08/2006
17	Stevens-Johnson Syndrome (Lyell's Syndrome) 01/2021 - 09/2006
16	Chemical and Drug Induced Liver Injury 01/2021 - 09/2005
10	Exanthema (Rash) 01/2021 - 06/2003
9	Neoplasms (Cancer) 01/2021 - 10/2004
8	Muscular Diseases (Myopathy) 02/2022 - 01/2010
8	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 05/2011
8	Insulin Resistance 01/2020 - 10/2003
8	Lipodystrophy 08/2013 - 10/2002
7	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 07/2011
7	Infections 12/2021 - 12/2004
6	COVID-19 01/2022 - 10/2020
6	Agranulocytosis (Granulocytopenia) 12/2021 - 10/2003
6	Asthma (Bronchial Asthma) 07/2021 - 01/2016
6	Genetic Predisposition to Disease (Genetic Predisposition) 01/2020 - 12/2007
5	Seizures (Absence Seizure) 01/2022 - 08/2006
5	Atrial Fibrillation 10/2021 - 10/2011
5	Hemorrhage 01/2020 - 07/2004
5	Rhabdomyolysis 12/2019 - 05/2014
4	Partial Epilepsies (Epilepsy, Partial) 01/2020 - 05/2004
4	Drug Hypersensitivity (Drug Allergy) 01/2017 - 02/2006
4	Allergic Contact Dermatitis 10/2015 - 04/2008
4	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2013 - 12/2004
3	Drug Resistant Epilepsy 01/2022 - 01/2013
3	Iatrogenic Disease 01/2021 - 02/2013
3	Cicatrix (Scar) 01/2021 - 11/2019
3	Drug Hypersensitivity Syndrome 01/2021 - 01/2018
3	Multiple Sclerosis 01/2021 - 08/2013
3	Myotoxicity 01/2020 - 09/2014
3	Acute Coronary Syndrome 01/2020 - 01/2017
3	Heart Failure 01/2018 - 01/2011
3	Liver Diseases (Liver Disease) 11/2017 - 07/2011
3	Alcoholism (Alcohol Abuse) 11/2017 - 01/2017
3	Acute Kidney Injury (Acute Renal Failure) 11/2017 - 01/2014
3	Clostridium Infections 11/2014 - 01/2014
3	Acidosis 05/2011 - 11/2009
3	Necrosis 05/2007 - 12/2004

Drug/Important Bio-Agent (IBA)

54	Pharmaceutical PreparationsIBA 01/2022 - 06/2003
21	HLA-B Antigens (HLA-B)IBA 01/2021 - 06/2004
21	Carbamazepine (Tegretol)FDA LinkGeneric 01/2021 - 04/2006
17	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 04/2006
17	abacavir (Ziagen)FDA Link 01/2020 - 05/2003
16	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2011
11	HLA Antigens (Human Leukocyte Antigens)IBA 01/2022 - 09/2006
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2007
10	AntigensIBA 01/2021 - 09/2002
10	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2019 - 01/2010
9	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 02/2006
9	HLA-B57 antigenIBA 01/2020 - 01/2012
8	Nevirapine (Viramune)FDA Link 01/2017 - 01/2006
7	Sulfamethoxazole FDA LinkGeneric 01/2021 - 09/2002
7	HLA-A31 antigenIBA 11/2019 - 02/2014
7	Floxacillin (Flucloxacillin)IBA 01/2019 - 06/2009
6	Clozapine (Clozaril)FDA LinkGeneric 12/2021 - 10/2003
6	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2021 - 01/2017
6	AnticoagulantsIBA 01/2020 - 06/2005
5	Antipsychotic Agents (Antipsychotics)IBA 12/2021 - 09/2014
5	Warfarin (Coumadin)FDA LinkGeneric 10/2021 - 07/2004
4	Genetic Markers (Genetic Marker)IBA 01/2022 - 02/2006
4	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/2021 - 07/2004
4	HLA-A Antigens (HLA-A)IBA 01/2021 - 03/2011
4	SteroidsIBA 04/2020 - 01/2016
4	AminoglycosidesIBA 03/2020 - 11/2017
4	Rosuvastatin Calcium (Crestor)FDA Link 03/2020 - 09/2014
4	Lamotrigine (Lamictal)FDA LinkGeneric 01/2020 - 06/2003
4	Biological ProductsIBA 01/2019 - 01/2014
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 10/2002
4	AntibodiesIBA 06/2017 - 10/2012
4	Imatinib Mesylate (Gleevec)FDA Link 01/2013 - 12/2004
3	HMGB1 Protein (HMG1)IBA 01/2022 - 06/2017
3	Vancomycin FDA LinkGeneric 01/2022 - 01/2019
3	HLA-DQB1 antigen (HLA DQB1)IBA 12/2021 - 05/2013
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 12/2021 - 01/2010
3	Dapsone FDA Link 10/2021 - 06/2015
3	Penicillins (Penicillin)FDA Link 01/2021 - 06/2009
3	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 01/2021 - 04/2009
3	LactamsIBA 01/2021 - 06/2012
3	Cytochrome P-450 CYP2C9IBA 01/2021 - 09/2009
3	Cytochrome P-450 CYP2C19IBA 01/2021 - 09/2009
3	Telmisartan (Micardis)FDA Link 01/2020 - 10/2015
3	HLA-C Antigens (HLA-C)IBA 01/2020 - 05/2013
3	HLA-DRB1 Chains (HLA DRB1)IBA 12/2019 - 10/2006
3	Cisplatin (Platino)FDA LinkGeneric 01/2018 - 01/2016
3	Baclofen FDA LinkGeneric 11/2017 - 01/2017
3	Allopurinol (Remid)FDA LinkGeneric 10/2017 - 01/2010
3	Creatine Kinase (Creatine Phosphokinase)IBA 08/2017 - 05/2014
3	Topiramate (Topamax)FDA LinkGeneric 01/2017 - 11/2009
3	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 01/2016 - 12/2013
3	4-phenylenediamine (p-phenylenediamine)FDA Link 10/2015 - 04/2008
3	Tuberculin (PPD)IBA 10/2015 - 04/2008
3	Peptides (Polypeptides)IBA 08/2015 - 06/2009
3	DNA (Deoxyribonucleic Acid)IBA 12/2014 - 06/2012
3	Piperacillin FDA LinkGeneric 06/2013 - 07/2011
3	Protease Inhibitors (Protease Inhibitor)IBA 10/2008 - 12/2004
2	Simvastatin (Zocor)FDA LinkGeneric 02/2022 - 06/2013

Therapy/Procedure

31	Therapeutics 07/2021 - 05/2004
5	Highly Active Antiretroviral Therapy (HAART) 01/2020 - 10/2008
5	Drug Therapy (Chemotherapy) 01/2018 - 10/2004